calcium transients during mitosis

Udo Merkel merkel at
Mon Mar 7 05:44:39 EST 1994

According to a minireview issued a while back (Peter Hepler, 
J Cell Biol 109, 1989, 2567) it is still unclear whether
calcium transients after fertilization have a role in 
triggering key events during mitosis (nuclear envelope 
breakdown, metaphase-anaphase transition, cytokinesis).

Now Steinhardt el al (Science 263,1994,390) report evidence 
for a role of calcium in the healing properties of disrupted
membranes (of sea urchin embryo and 3T3 cells).  They report 
also on an antagonism of Ca++ and Mg++ that is in a way 
reminiscent of phenomena observed in neurosecretion.

Could it be that even the mitotic phases don not depend so 
much on a calcium signal per se but rather on the relative 
concentrations of calcium and an antagonist (magnesium?) 
Any references on this issue?

Udo Merkel                                  merkel at
Institut fuer Informatik, Universitaet Stuttgart       Tel: (+49 711) 7816-366
Breitwiesenstrasse 20-22, D-70565 Stuttgart, Germany   Fax: (+49 711) 780-1044

He makes himself me nothing, you nothing out of the dust.  (Automated transl.)

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