calcium transients during mitosis

Udo Merkel merkel at bs4.informatik.uni-stuttgart.de
Mon Mar 7 05:44:39 EST 1994


According to a minireview issued a while back (Peter Hepler, 
J Cell Biol 109, 1989, 2567) it is still unclear whether
calcium transients after fertilization have a role in 
triggering key events during mitosis (nuclear envelope 
breakdown, metaphase-anaphase transition, cytokinesis).

Now Steinhardt el al (Science 263,1994,390) report evidence 
for a role of calcium in the healing properties of disrupted
membranes (of sea urchin embryo and 3T3 cells).  They report 
also on an antagonism of Ca++ and Mg++ that is in a way 
reminiscent of phenomena observed in neurosecretion.

Could it be that even the mitotic phases don not depend so 
much on a calcium signal per se but rather on the relative 
concentrations of calcium and an antagonist (magnesium?) 
Any references on this issue?

------------------------------------------------------------------------------
Udo Merkel                                  merkel at informatik.uni-stuttgart.de
Institut fuer Informatik, Universitaet Stuttgart       Tel: (+49 711) 7816-366
Breitwiesenstrasse 20-22, D-70565 Stuttgart, Germany   Fax: (+49 711) 780-1044

He makes himself me nothing, you nothing out of the dust.  (Automated transl.)
------------------------------------------------------------------------------



More information about the Cellbiol mailing list