Xenobiotic Nitro-Reduction Enzymes?

Dr. S. Spiro sspiro at crc.ac.uk
Tue Mar 8 13:32:46 EST 1994


In article <2l7tfgINNm88 at dns1.NMSU.Edu> malucero at nmsu.edu (Mary Elyse Lucero) writes:
>Does anyone out there know of any reviews or other references describing
>enzymes or classes of enzymes which are responsible for reduction of
>nitro- groups on nitroaromatics or other xenobiotic compounds?  In vivo,
>these nitro groups are often converted to amino-groups.  This has been
>well documented through radiolabeled metabolite studies.  However, these
>studies rarely examine the enzymes involved.  
>
>I have read up on nitrate and nitrite reductase enzymes, but so far
>have found nothing to suggest that these enzymes act on anything other
>than free nitrate/nitrite.  
>
>I would very much appreciate any references you can suggest. 
>
>Thanks!
>
>Mary Lucero
>
Try looking for nitroreductase or azoreductase.  A recent reference
is Appl Env Microbiol (1993) 59:1731-1734

Good Luck!

Stephen Spiro
University of East Anglia, Norwich
s.spiro at uk.ac.uea




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