Xenobiotic Nitro-Reduction Enzymes?
Dr. S. Spiro
sspiro at crc.ac.uk
Tue Mar 8 13:32:46 EST 1994
In article <2l7tfgINNm88 at dns1.NMSU.Edu> malucero at nmsu.edu (Mary Elyse Lucero) writes:
>Does anyone out there know of any reviews or other references describing
>enzymes or classes of enzymes which are responsible for reduction of
>nitro- groups on nitroaromatics or other xenobiotic compounds? In vivo,
>these nitro groups are often converted to amino-groups. This has been
>well documented through radiolabeled metabolite studies. However, these
>studies rarely examine the enzymes involved.
>I have read up on nitrate and nitrite reductase enzymes, but so far
>have found nothing to suggest that these enzymes act on anything other
>than free nitrate/nitrite.
>I would very much appreciate any references you can suggest.
Try looking for nitroreductase or azoreductase. A recent reference
is Appl Env Microbiol (1993) 59:1731-1734
University of East Anglia, Norwich
s.spiro at uk.ac.uea
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