cytokines, internalised?

P Mulderry mulderry at
Mon Mar 28 05:53:45 EST 1994

MJ Duggan <sgex400 at> writes:

>Dear netters,

>I know that several (all?) of the growth factors (e.g. NGF) are 
>internalised after they bind to their receptors. But I would
>like to know if this is true for the cytokines as well. I have tried
>looking in several textbooks but can find no mention of such a
>mechanism. Does this mean that the cytokines are not internalised,
>that no one has looked (!), or that it happens but nobody thinks
>that it is important? 

Leukemia inhibitory factor is internalized by sensory neurons.
See Hendry et al., J. Neurosci. v.12 p.3427 (1992)
    Curtis et al., Neuron v.12 p.191 (1994)

More information about the Cellbiol mailing list