calmodulin inhibiter

[Colin Rasmussen]

On 4 Oct 1994, Ben Kruskal wrote:

> Several possibilities:
>     -Phenothiazines such as trifluoperazine (TFP) inhibit calmodulin,
> although not specifically.  Of interest, TFP inhibits phagocytosis by
> J774 cells.  (Horwitz et al.,  JCB 91:798 (1981)  )
>     -W-7 is a naphthalenesulfonamide drug which inhibits calmodulin,
> again without absolute specificity.
>     -Calmidazolium (Janssen Pharmaceuticals) is a non-phenothiazine,
> non-naphthalenesulfonamide  calmodulin antagonist which is more
> specific.


To be accurate, none of the calmodulin inhibitors are "specific" as they 
affect other cellular functions due to their hydrophobic nature.  The 
only specific way to ablate calmodulin activity is either through 
expressing antisese RNA, or by gene disruption (not possible for the 
original requestor).