genetics research

[anthonyp at scripps.edu]

In article <940906093444.26c0118a at hopi.azcc.arizona.edu>, 
<JMARTINEZ at HOPI.AZCC.ARIZONA.EDU> writes:
> A similar scenario applies to 291 cells.  If memory serves me
> correctly these cells are an SV40 virus transformed cell line.  The large T
> antigen of SV40 virus binds to p53 and inactivates it.  The p53 protein 
levels
> in 291 cells should be quite high because binding with TAg also prevents its
> degredation.  

Never heard of 291's, but 293 (ATCC-CRL 1573) are a human epithelial cell line 
trasformd by adenovirus E1A.  I believe the original poster asked about 293.

E1A also interacts with P53.  But I have never checked my 293's specifically 
for p53.


-tony