genetics research

anthonyp at anthonyp at
Tue Sep 6 16:12:16 EST 1994

In article <940906093444.26c0118a at>, 
> A similar scenario applies to 291 cells.  If memory serves me
> correctly these cells are an SV40 virus transformed cell line.  The large T
> antigen of SV40 virus binds to p53 and inactivates it.  The p53 protein 
> in 291 cells should be quite high because binding with TAg also prevents its
> degredation.  

Never heard of 291's, but 293 (ATCC-CRL 1573) are a human epithelial cell line 
trasformd by adenovirus E1A.  I believe the original poster asked about 293.

E1A also interacts with P53.  But I have never checked my 293's specifically 
for p53.


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