RNeubig at umich.edu
Sat Dec 2 13:34:43 EST 1995
Cornelius Krasel wrote:
> Deborah (IZZY32F at MVS.OAC.UCLA.EDU) wrote:
> > How does forskolin function with respect to adenyl cyclase activity
> > and cAMP production?
> > How does forskolin act like a mimetic?
> AFAIK the mechanism how forskolin activates cyclase is unknown. If
> I remember correctly, the alpha subunit of Gs must be present to
> achieve full forskolin activation (I could be wrong).
Cornelius is essentially correct. Forskolin directly activates
adenylyl cyclase but for some subtypes of AC its action is potentiated
by the additional presence of activated G-alpha-s.
Rick Neubig RNeubig at umich.edu
University of Michigan Phone (313) 763-3650
http://www.umich.edu/~rneubig FAX (313) 763-4450
More information about the Cellbiol