Mepacrine (Quinacrine ) as a PLA2 inhibitor

alan alan
Thu Jul 6 13:44:46 EST 1995


In article <3tbule$74d at dux.dundee.ac.uk>, Alan Monaghan <a.s.monaghan at dundee.ac.uk> says:
>
>I am very interested in the effectivness of Mepacrine
>(Quinacrine) as a PLA2 inhibitor, it may be described
>as a non-selective phospholipase inhibitor, or some even
>describe it as being ineffective on PLA2, but I am interested
>to hear from anyone who has used it to inhibit any
>type of phospholipase, and how effective it was.
>
>Yours sincerely, G. G. MacGregor
>g.g.mcgregor at dundee.ac.uk
>


Mepacrine has been tested against PLA2 activity in saliva and
salivary glands (homogenates and whole glands) from ticks.  It 
proved to be ineffective against both the secreted and intra-cellular
tick PLA2s -however, we didn't really find any adequate inhibitors (except
substrate analogues).  The literature is full of instances where mepacrine
is a very potent PLA2 inhibitor.




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