1 Brown/1 Blue eye

Jon Nakamoto jnakamot at ucla.edu
Mon Nov 27 05:35:37 EST 1995

Why do Husky dogs so often have one blue eye and one brown eye? I'd love
to hear what you come up with.

One entity to watch for in humans is Waardenburg syndrome (basically a
localized hypopigmentation which can affect the hair and iris/fundus
pigmentation, as well as related auditory structures). You can have a
single blue iris in someone who should have brown eyes (e.g., an Asian
subject). Is there a white forelock? Any hearing loss? Any vision

Also, some drugs (e.g., imipramine) have been associated with darkening of
iris pigmentation after long-term use. I doubt this is operative here (and
wouldn't explain the unilateral changes). 

If you get the authoritative answer, let me know!


Jon Nakamoto, M.D.
UCLA Medical Center, Los Angeles, CA 90024
jnakamot at ucla.edu

In article <bohmfalk-2611951308220001 at pm1-8.tcgcs.com>, bohmfalk at tcgcs.com
(John Bohmfalk) wrote:

> I have a student who has one beautiful brown eye, and one beautiful blue
> eye.  Do any of you know the genetic/molecular mechanism behind this
> phenomenon?  Any idea how common it is?  I would appreciate any
> information, or references.
> Thanks all.
> John Bohmfalk
> Biology Dept.
> Hastings College
> Hastings, NE  68901
> bohmfalk at tcgcs.com

Jon Nakamoto
jnakamot at ucla.edu

More information about the Cellbiol mailing list