hsp70:folding:chaperonins

[alex emil kentsis]

as well as i understand it,
all hsp proteins perform some type of chaperonin function, and as such
actively participate in facilitating the folding process. 
in general, i think that folding begins with the output of the first four 
residues from the ribosome, when the possibility for forming a 1-4 hydrogen
bond becomes available. in general, it is hyudrogen bond formation between close
residues that is the early event in protein folding, with the subsequent 
secondary element formation. 
-alex.


L.Kempster (l.kempster at ic.ac.uk) wrote:
: Can anyone direct me to or does anyone have any information on whether
: protein folding (not hydrophobic residue protection) during biosynthesis
: only occurs in association with the chaperonins, or does protein folding
: occur before this i.e. in association with Hsp70/Hsp40 etc.

: Thanks in advance

: Lee Kempster
: Imperial College