massa at cgl.ucsf.edu
Fri Jun 21 15:22:58 EST 1996
On Sun, 16 Jun 1996, Gabi Gerlitz wrote:
> Hello everyone,
> Has someone heard about the new molecule involved in
> apoptosis which was found in weizman institute of science in israel?
> If you know something about it please write.
Its a protein called MACH which binds to FADD(MORT1) and apparantly
contains a domain homologous to the ICE/ced-3 family. Overexpression
causes apoptosis and forms with partial protease regions inhibit Fas and
TNF-R signalling.The article describing it is-- Boldin, M.P, T.M.
Goncharov, Y.V. Goltsev and D. Wallach, Involvement of MACH, a novel
MORT1/FADD-interacting protease, in Fas/APO-1- and TNF-Receptor-induced
cell death Cell 85, 803-815, 1996. Another paper in the same issue
describes the same or very similar molecule (I have only the abstracts so
it is difficult to tell) which they call FLICE (Muzio et al.Cell 85,
817-827,1996). Hope that answers the question.
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