hepatocytes - why polyploid/binucleate?
GOODE at ZOOL.UMD.EDU
Thu Mar 28 13:09:38 EST 1996
On Mon, 25 Mar 1996 09:54:57 -0500
> Can anybody explain to me why hepatocytes are frequently polyploid or
> binucleate? What is the advantage? TIA.
> Tom Phillips (tphillips at biosci.mbp.missouri.edu)
Sometimes binucleate or polyploid cells occur because a highly
differentiated cell has difficulty physically dividing its highly
structured cytoplasm. This is something I saw in cardiac muscle cells
(Goode, D., Cytobiologie 11: 203-229)
and may be allowed in the last division because it causes no great
problems and therefore is not a significant disadvantage to be
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