Mitochondrial disorder

[Ricardo Azpiroz]

Hello. 
I hate to send this out to the whole group, but somebody out there started
this with a legitimate question (albeit of personal nature), and I don't
want non-scientists to be misled. If anyone out there is trying to learn
about mitochondrial disorders, I strongly advise not to consider the post
that follows as scientifically sound. The sender, who failed to identify
hin/herself by name, is obviously not a scientist and not even
"scientific" as stated. The advice given in that post appears to be
typical health-food pseudoscience, and may result in unproductive expense
of time and money, not to mention dashed expectations.

Ricardo Azpiroz

PS: No slight intended to health foods; only to the pseudoscience
sometimes associated with them.


On 24 Nov 1996 rand61711 at aol.com wrote:

Try book: Mitochondrial Biogenesis and Breakdown  by  Valentin
Luzikov..the top world reseracher on mitochondria..available from
Consultant's Bureau, NY NY USA. or Moscow State University, Moscow
Russia..  It is available in many University Libraries, including Un. of
Tex Dallas.

It is a very difficult book which I understant about 30% of and I am
scientific.
Main things I learned are that degradation is most caused by excess iron,
poor anit-oxidant concentration (Vit E, Vit C, Bioflavinoids B-Compolex,
B2, B5, B6 Ascorbyl Palmitate, selenium), low serum albumin (egg white-
requires high supplements with Biotin at different time of) , low
magnesium, low Krebs cycle substrate nutrients (citrates, malates,
aspartates etc), Low phosphotidylcholin (some powdered lecithins), trace
mineral imbalance-do hair analysis.
(Manganese, molybdenum, copper levels are critical)
High zinc and high chlorides are harmful.  A good level of Glutathione and
Glutathioine Peroxidase balance is required.  Also, chromium picolinate is
related to energy/glucose cycle.

When capable, according to Luzikov, the best thing for mitochondria is
activity.  ie: get them working again.  Slow, generous activity when they
are working somewhat seems like the way (walking?)  Also, B5 pantothenic
acid has been shown, in about 500-600 mg /day (spread out) to increase
stamina by 2 to 3 times.   This stuff worked for me. I'm 47 and can easily
run 2 miles, fast and not be tired.  Lastly, calcium/magnesium ratios are
critical and are affected by inactivity. Bouncing and jogging on hard
surface will help balance with VitD natural and boron trace with horstail
silica.   Most of these products are available from a health food store
chain-Whole Foods Inc. of USA.  Calcium excess affects mitochondria.  Form
best, i don't know, probably citrate/malate. Calcium too low stops RNA
release from nucleus.

This is oddly one of the few things which, when properly nourished and
then used, fixes itself quickly. Totally lost mitochondria I think are not
rebuilt, but fair amount of brewers yeast might be good for amino acids
and odd B vitiamins. 

Good luck.  Let me know how it works out..   
This is not medical advice. Anything you do should be after your due
diligence.
Bob.  



----------------------
Ricardo Azpiroz
Department of Biochemistry
Life Sciences South
University of Arizona
Tucson AZ 85721-0106

azpiroz at U.Arizona.EDU