Emery H. Bresnick ehbresni at FACSTAFF.WISC.EDU
Wed Oct 2 14:48:38 EST 1996

                             October 1, 1996

        A Postdoctoral Research Associate position is currently available
in my laboratory to participate in NIH-funded studies on mechanisms of
locus control region function and erythroid-specific gene transcription. 
Questions being investigated include - how is the human b-globin lcr shared
by multiple promoters on a chromosome, what are the requirements for
long-range gene activation by lcrs, and do the protein components of the
lcr form ordered nucleoprotein complexes?

        A second project focuses on the TAL1 protein, an erythroid-specific
transcription factor and a crucial regulator of mammalian development.  The
regulatory regions of the TAL1 gene are disrupted by a chromosomal deletion
in patients with acute T cell lymphocytic leukemia.  This deletion results
in ectopic expression of TAL1 in T cells, and thus may be directly involved
in leukemogenesis.  One aim is to delineate the cis-acting elements and
trans-acting factors which drive TAL1 transcription in erythroid and T
cells.  A second aim focuses on identifying target genes for TAL1.

        Potential applicants should submit a brief description of research
interests, a curriculum vitae, and the names of three individuals for
recommendations to:

Emery H. Bresnick, Ph.D.
University of Wisconsin-Madison
Department of Pharmacology
1300 University Avenue
Madison, WI 53706

TEL. (608) 265-6446
E-Mail - ehbresni at facstaff.wisc.edu

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