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Fluorescent lipid oxidation indicator

Dick Haugland dick at probes.com
Wed Feb 19 20:31:44 EST 1997


I have not heard of anything called SNAR and probably would have if that
name is correct.

There has not been much developed along these lines.  What is available
is described in Chapter 21 of Molecular Probes' Handbook of Fluorescent
Probes and Research Chemicals, which is at our Web site
(http://www.probes.com).  There is a reagent diphenyl-1-pyrenylphosphine
(DPPP) that is essentially nonfluorescent but reacts with lipid
hydroperoxides to form a fluorescent product (a phosphone oxide) that
may be useful, although it does not seem to have been used that way. 
There are other reagents such as reduced fluoresceins and reduced
rhodamines that are also oxidized to fluorescent products in viable
cells.  However they are less likely to be useful to follow lipid
oxidation.

Dick Haugland, President
Molecular Probes, Inc.



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