Ascorbic Acid and Fibroblasts
gordonr at cc.umanitoba.ca
Thu Feb 27 23:20:42 EST 1997
It's nice to see the blunt question of differentiation in such cells. I
assume you mean in culture?
I don't have an answer, but we've been working on differentiation in intact
embryos, and find that each step of differentiation seems to be triggered
by an observable wave that crosses a tissue. It would be interesting to
learn whether similar waves accompany differentiation in tissue culture.
Perhaps ascorbic acid would alter differentiation waves? A couple of key
papers are listed below.
Best, -Dick Gordon
>Is there anybody out there who knows if ascorbic acid (vitamin C) causes
>differentiation of fibroblasts. It has been established that ascobate does
>induce the synthesis of collagen. Indeed, do fibroblasts undergo
>differentiation? Differentiation of fibroblasts seems to be a confusing
>issue. There seems to be some confusion as to whether fibroblasts can
>undergo differentation like epithelial cells and lymphocytes. If there is
>anyone who has some insight into this process your help will be enormously
>Dept. of Med. Micro. Immunol.
>bijur.1 at pop.service.ohio-state.edu
Bjorklund, N. K. & R. Gordon (1994). Surface contraction and expansion
waves correlated with differentiation in axolotl embryos. I. Prolegomenon
and differentiation during the plunge through the blastopore, as shown by
the fate map. Computers & Chemistry 18(3), 333-345.
Brodland, G. W., R. Gordon, M. J. Scott, N. K. Bjorklund, K. B. Luchka, C.
C. Martin, C. Matuga, M. Globus, S. Vethamany-Globus & D. Shu (1993).
Furrowing surface contraction wave coincident with primary neural induction
in amphibian embryos. J. Morph. 219, 131-142.
Gordon, R. & N.K. Bjorklund (1996). How to observe surface contraction
waves on axolotls. Int. J. Dev. Biol. 40(4), 913-914.
Gordon, R., N. K. Bjorklund & P. D. Nieuwkoop (1994). Dialogue on embryonic
induction and differentiation waves. Int. Rev. Cytol. 150, 373-420.
Dr. Richard Gordon, Department of Radiology
University of Manitoba, Room ON104, Health Sciences Centre
820 Sherbrook Street, Winnipeg, MB R3A 1R9 Canada
Phone: (204) 789-3828, Fax: (204) 787-2080, Home: (204) 589-0411
E-mail: GordonR at cc.UManitoba.ca
More information about the Cellbiol