Ascorbic Acid and Fibroblasts

[Gautam Bijur]

Hi

Is there anybody out there who knows if ascorbic acid (vitamin C) causes
differentiation of fibroblasts. It has been established that ascobate does
induce the synthesis of collagen.   Indeed, do fibroblasts undergo
differentiation?  Differentiation of fibroblasts seems to be a confusing
issue.  There seems to be some confusion as to whether fibroblasts can
undergo differentation like epithelial cells and lymphocytes.  If there is
anyone who has some insight into this process your help will be enormously
appreciated.

 Thanks

Gautam Bijur
Dept. of Med. Micro. Immunol.
bijur.1 at pop.service.ohio-state.edu