G-proteins and signal transduction

Donald Johnston DJ.50 at worldnet.att.net
Wed Mar 12 18:23:52 EST 1997

G-proteins provide the cytoplasmic interface between transmembrane
receptors and signal transduction pathways.  They either directly regulate
the function of serine/threonine kinases or bind to proteins that do.
Calcium levels are held at very low levels in a cell and respond to
intracellular second messengers or voltage changes across the membrane with
an elevation in concentration.  This elevation affects the activity and
positioning of kinases and other enzymes which usually attach to membranes
in response to calcium spikes.  The literature is filled with examples of
this, (check Annual Reviews of Biochemistry) and there are good discussions
in Alberts..

ylee at REED.EDU wrote in article <3324B346.13C8 at reed.edu>...
> Hello, I am a hapless biology undergraduate reading about signal
> transduction and second messengers.  Can anyone out there explain why
> G-proteins and Ca2+ play such a diverse role in cellular regulation and
> signal transduction?  i haven't found any information on that in the
> literature.  Thanks for your help!

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