Oncogene activation by diff.localisation??

Martin Offterdinger a8803349.nospam at unet.univie.ac.at
Wed Aug 19 01:45:33 EST 1998

Hi everyone!
I am looking for references describing oncoprotein activation and
deactivation by altered localisation. The only case I know of is ras:
this oncogen can be deactivated by inhibiting membrane localisation,
(farnesyl-transferase-inhibitors), because ras is only active, when
localised at the inner side of the cell membrane. Are there any other
examples. Any hint (including references) will be appreciated!!
Thank you!
Martin Offterdinger
Internal Med.I,Dept. Oncology
University of Vienna
E-Mail:a8803349.nospam at unet.univie.ac.at
(remove nospam before mailing)

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