Oncogene activation by diff.localisation??
a8803349.nospam at unet.univie.ac.at
Wed Aug 19 01:45:33 EST 1998
I am looking for references describing oncoprotein activation and
deactivation by altered localisation. The only case I know of is ras:
this oncogen can be deactivated by inhibiting membrane localisation,
(farnesyl-transferase-inhibitors), because ras is only active, when
localised at the inner side of the cell membrane. Are there any other
examples. Any hint (including references) will be appreciated!!
Internal Med.I,Dept. Oncology
University of Vienna
E-Mail:a8803349.nospam at unet.univie.ac.at
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