Telomeric Theory of Aging

Austin Seo (Hae Jin) haejin at
Tue Aug 18 21:13:32 EST 1998

The other issue about "life-extension" is that cells must die over the course
of development.

So...if you do a telomerase knock-in, there is a distinct possibility that you
will screw up the development of an organism. A good example is the caspase
knockout mice (though unrelated mechanistically as far as we know): these
apoptotic enzymes are required for the normal development of brain (among other
things) and are embryonic lethal.

ufotruth at wrote:

> 1) It could help determine whether immortalizing all the cells, at
> least all the dividing cells, in an organism would cause a higher rate
> of cancer or tumors.
> 2) It could help determine if immortalizing all the cells in a mouse
> would extend the life span of mice who were resistant to non-aging
> related dieseases. You see even though telomerase therapy would
> probably not help those who die from non-aging related dieseases it
> might help those that do die of aging relating dieseases.
> 3) It would help determine if immortalizing all the dividing cells in
> an organism would help non-dividing cells live longer because they
> would not accumilate as much damage from being poisoned by the aging
> and dying dividing cells.


Austin Seo (Hae Jin)

Graduate Programme in Neuroscience
Centre for Molecular Medicine and Therapeutics
e-mail: haejin at

More information about the Cellbiol mailing list