Current Research Into Telomeres III
tmatth at netcom.ca
Tue Sep 1 23:23:54 EST 1998
> Dr R. Effros at U.C.L.A. is researching the effects of telomeric shortening
> on the T-Cells in the immunological systems of the elderly. Her observations
> include the dominance of senescent "memory" T-cells in aged individuals
To be precise, are you saying that Rita Effros has found that the
*majority* of memory T-cells are now longer able to divide and produce
more such T-cells? Do you have a reference for this?
> may "prevent renewal of the T-cell pool with more functional T-cells". The
> implications being that the restoration of replicative capacity in those
> T-cells that are approaching senescence could have the effect of restoring
> functioning of some parts of the immunological system in the elderly.
Or since now you say "are approaching senescence" do you mean that she
found that the T-cells had reduced replicative ability in older people?
(which would not necessarily be related to any telomere shortening).
> Rawes V, Kipling D, Kill IR and Faragher RG at The University of Brighton,
> UK, have demonstrated results that "suggest that the process of senescence is
> a common feature of different cell lineages but that the specific rate can
> differ between them."
Do they mean different "rate" or after a different number of divisions?
> Thus the cell lines constituting the endothelial cells
> in the vascular system may be experiencing telomeric loss faster than other
> cell lines in the body. This may be a factor underlying age-related
> "disease" progression in some systems of the body.
Certainly, because division "rate" is highly different in different
dividing systems and under different life, and health (sometimes
> Tahara H, et al, at Hiroshima University School of Medicine, Japan,
> demonstrated that "a significant proportion of WRN, (Werner's syndrome), cell
> strains showed drastic shortening or lengthening of telomere lengths during
> cell passages compared with normal cell strains" This confirms earlier
> studies that Werner's syndrome and the childhood aging disease progeria
> result from errors in the system(s) that maintain telomeric length.
But it doesn't say anthing about whether these diseases are related to
Sorry, to be always playing the "skeptic", Tom.
I found your post to be most interesting, as usual.
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