gnome at istar.ca
Mon Sep 7 03:35:04 EST 1998
In article <6safgs$fvk$1 at birch.prod.itd.earthlink.net>,
excelife at earthlink.net (Excelife) wrote:
>It's an excellent article and I would like to credit its creator.
[paper by J Clark]
>Senescence, Telomeres and Aging
>Testosterone and prostate telomerase Feb 1998
>Effectively regenerating a younger prostate. From a purely aging
>interest, it testosterone a telomerase suppresser? It would be
>interesting to assay non-sex tissue for telomerase during this type
Testosterone suppresses IL-6. IL-6 acts on stem cells, increasing
telomerase. It also is involved in tissue degradation by its action
Straub RH, Konecna L, et al. 1998 Jun. Serum dehydroepiandrosterone
(DHEA) and DHEA sulfate are negatively correlated with serum
interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from
mononuclear cells in man in vitro: possible link between
endocrinosenescence and immunosenescence. J Clin Endocrinol Metab.
"Immunosenescence may be directly related to endocrinosenescence,
which, in turn, may be a significant cofactor for the
manifestation of inflammatory and age-related diseases."
Spencer NF, Daynes RA. 1997 May. IL-12 directly stimulates
expression of IL-10 by CD5+ B cells and IL-6 by both CD5+ and CD5- B
cells: possible involvement in age-associated cytokine
dysregulation. Int Immunol. 9(5):745-754.
"Treatment of aged animals with low doses of dehydroepiandrosterone
sulfate, previously established to be immunocorrective in
immunosenescent animals, reduced the age-associated alterations in
IL-12 mRNA and protein expression. The mechanisms responsible for
the abnormal constitutive expression of inflammatory cytokines by
the macrophages of aged animals may play an important afferent
role in establishing the immunosenescent phenotype."
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