> What you're actually saying, then, is that anyone alive today at 120
> yrs. of age, must have got there strictly by way of a lifetime of severe
> calorie restriction; is that correct?
Maybe, maybe not. Since we don't know how it works we don't know that there are
not a variety of ways to cause the same metabolic changes. Maybe they ate a lot of
something that caused an effect similar to CR. Maybe they were genetically
blessed. Who knows... In a complex system (such as the human body) there are
often multiple paths to the same outcome, as a result of intertwined pathways,
> In aging research, just like any other scientific endeavor, doesn't it
> makes perfect sense to go after the low hanging fruit first? Especially
> since it appears that, in this case, discovering the mechanism
> underlying CR might shed light on the more fundamental processes at
> work, and might generate lots of money for further research.
If you consider CR research low-hanging fruit. I do, but I don't think Tom does.