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Antiaging Research Priorities [was Re: Major Criticisms of

andrewmason at my-dejanews.com andrewmason at my-dejanews.com
Sun Sep 20 23:15:46 EST 1998

> Let's see, for CR to be beneficial we only have discover the underlying
> mechanism, find some way to make it work on people already past their prime,
> and and find a way to mimic its effects since the diet itself would have to
> be close to starvation levels.
> Boy that sure sounds like low-hanging fruit to me!!!
> To find out if the Telomeric Theory of aging can actually alter the human
> life span we have to insert hTRT, the catalytic protein subunit of
> telomerase, into a few key cellular systems of the body.  Of course we do
> have to try it on animals first so there is going to be a delay.
> But since research into CR is so much more advanced and so simple we should
> just forget about telomeres.


you forgot to mention the benefits -

CR: possibly 50% greater lifespan, including a proportionally longer period of
old age, complete with its problems of physical and mental impairment.

Telomere therapy: significantly longer life with rejuvenation (or at least
halting of aging) of organs, muscle, skin and bone.

Sounds like an easy choice to me.

I am not saying that telomere therapy is guaranteed to eventuate, but we have
a well supported hypothesis that is testable in the short term and could
prove to be the central mechanism of aging. It would make sense to
concentrate resources in this area in the short term to at least determine
whether resetting or preserving telomere length in vivo can extend life or
immortalise an organism.

Telomeres are having a tremendous amount of interest focussed on them by the
research community. This is because they show promise in the diagnosis and
treatment of both AIDS and cancer. I suspect the work required to test and
support or disprove the telomere theory of aging will be done in the next few
years. If positive results do eventuate you can be sure the research will take
off by itself, as drug companies begin to appreciate the profit potential of a
drug or therapy that could make the demand for viagra seem trivial.


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