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Antiaging Research Priorities [was Re: Major Criticisms of

Excelife excelife at earthlink.net
Mon Sep 21 22:23:46 EST 1998

In article <YryN1.370$YP5.799530 at tor-nn1.netcom.ca>, dlj at pobox.com says...
>Andrew Mason sensibly wrote:
>>>Telomeres are having a tremendous amount of interest focussed on them by
>>>research community. This is because they show promise in the diagnosis and
>>>treatment of both AIDS and cancer. I suspect the work required to test and
>>>support or disprove the telomere theory of aging will be done in the next
>>>few years. If positive results do eventuate you can be sure the research
>>>will take off by itself, as drug companies begin to appreciate the profit
>>>potential of a drug or therapy that could make the demand for viagra seem
>I think this set of strategies is plausible as far as it goes -- but it only
>goes as far as cellular health. All "organisms", which is to say anything
>bigger than your friendly local e. coli, are alliances of cells, in the good
>metaphor of Lynn Margolis and her co-workers. Aging, it seems to me is as
>much or more an attribute of the alliance as it is of the individual cells.
>Thus cellular health would seem necessary but not sufficient for
>life-extension at the level of, say, the large mammal.
>Hence endocrinological strategies would seem to me to be a good place to
>look. (Sez the guy who made a fool of himself by writing in a moment of
>pique against the idea of mebabolic individuality a couple of weeks ago.
>:-) )  The essence of any alliance is the communication between the members,
>and for the body as a whole the endocrine system seems to be all the major
>media. The nerves may carry the mail, but the enzymes write the legislation
>and negotiate the treaties.


Telomeres have the potential of being the cellular clock for the production 
of hormones and enzymes over the course of aging as demonstrated when the 
introduction of hTRT allows the cell to express a phenotypically youthful 
state.  Additional research showing telomeres to be involved in the 
transcriptional silencing of various genes suggest the mechanism by which 
this could occur.

As of this date, however, this is by no means clear and various other 
processes are likely involved in control of the endocrine system.

As most readers of this group know, I am posting a series on the telomeric 
theory of aging and am at the point of writing on related aging research.

I have a few references to aging and the endocrine system and have done a 
Medline search on the subject.  I am not sure if I have found the most 
significant studies in this area.  So if anyone knows the cites for any good 
studies into research into aging and the endocrine system they would be 
helpful in my series.

Thanks in advance for any help provided!  

Thomas Mahoney, Pres.
Lifeline Laboratories, Inc.

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