question: caveolae

Robert Jan Veldman rojav at wanadoo.fr
Tue Sep 28 13:26:45 EST 1999


Dear Collegues,

Does anyone know of a method to disrupt caveolae in cultured cells? I
tried cyclodextrin and sphingomyelinase treatments in order to remove
cholesterol or sphingomyelin, respectively. However, both functionally
and structurally the caveolae in my system (human fibroblasts) seem to
'survive' these treatments. Every tip is welcome!

Robert Jan Veldman, PhD
INSERM unit 466
Toulouse, France





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