Peter Butler peter.butler at
Mon Apr 10 05:51:55 EST 2000

Kluwer Academic Publishers is considering the launch of a new journal,
"BioComplexity". I would be grateful if you would spare a few minutes to
read the
following and to answer the survey. Please return your comments directly
to me.

Many thanks in advance,
Peter Butler
Publishing Editor
Kluwer academic publishers

E-mail: peter.butler at
Fax No: +31-78-639-2377


'from molecules to the living cell'

Aims & Scope

Emergent properties can arise in nonlinear interactions. Living cells
and the
organisms composed thereof owe there functionality to such emergent
properties. This
functionality includes energy coupling and allosteric regulation (which
require the
interaction of protein domains), metabolic regulation (which involves
regulation, and signal transduction, hence the interaction of entire
macromolecules), and cell and organ functioning (which depends on the
interaction of organelles and cells). Often the formation of the
accompanies these functional aspects. The nonlinear nature of the
interactions makes
the emergent properties difficult to understand in terms of molecular
yet this understanding is the ambition of the field of BioComplexity. To
this ambition, at each level of emergence precise experimentation,
preferably inside
the living system, should be accompanied by quantitative analysis and
It is the tenet of the field of BioComplexity that at the various levels
emergence, similar principles appear to operate. The Journal focuses on
understanding of these principles.

BioComplexity will publish experimental and theoretical contributions
preferably combinations thereof) concerning emerging properties in the

· Mechanisms of free energy transduction through domain interactions
with proteins
· Coupled molecular motors
· Flux induced structures
· Non equilibrium regulation of gene expression, e.g. by maintenance of
energized DNA structures
· Macromolecular crowding in living cells
· New technologies to inspect emergent properties in living systems
· Molecular neural networks in living cells
· Metabolite and signal channeling
· Maintenance and replication of cell structures
· Epigenetic control of gene expression; gene silencing mechanisms
· Hysteresis and self organization in and between living cells
· Autonomous oscillations (cell-cycle, calcium, glycolytic, cell-cell
· Entrainment
· Cell-cell communication
· The behaviour of individual molecules in interaction
· The special properties of heterogeneous biological systems
· Engineering the complex, live cell
· Metabolic and Hierarchical Control Analysis
· Generation and maintenance of (non-equilibrium) structures (cell
infrastructure, chaperonins, DNA gyrase)
· Intracellular active transport of macromolecules
· Catalysis by non-equilibrium structures (e.g., enzymes catalyzing
processes in a metastable state)
· Where the living cell differs from its in vitro analogues ('Entering
the living cell')

Each issue of BioComplexity will contain a review of one aspect of the
field, a
review of new experimental techniques, plus a series of papers with the
most recent
primary results. All contributions will be peer-reviewed by independent
plus one member of the editorial board.

Hans V. Westerhoff
Faculty of Biology
Free University, Amsterdam

Editorial Board
Steve M. Block (Princeton)
Natalie S. Cohen (Los Angeles)
Jonathan Cooke (London)
Karel van Dam (Amsterdam)
Roel van Driel (Amsterdam)
Hans Frauenfelder (Los Alamos)
Albert Goldbeter (Brussels)
Rienk van Grondelle (Amsterdam)
Reinhart Heinrich (Berlin)
Tom M. Jovin (Gottingen)
Douglas B. Kell (Aberystwyth)
Martin J. Kushmerick (Washington)
Sidney Kutsu (Stanford)
Brian W. Matthews (Eugene)
Keith Moffat (Chicago)
Rick Morimoto (Northwestern)
Friederick C. Neidhardt (Ann Arbor)
Dieter Oesterhelt (Martinsried)
Steve Oliver (Manchester)
Rudolf Rigler (Stockholm)
John Walker (Cambridge)
John E. Wilson (East Lansing)
Alan P. Wolffe (Bethesda)

1. Do you think the proposed journal would fill a need?

2. Do you agree with the Aims & Scope and the Rationale of the
Journal?                                       yes/no
(If not, please comment)

3. Do you agree with the proposed Editors and
Editor-in-Chief of the Journal?   yes/no
(If not, please comment)

4. Do you think that there is enough high quality material
to fill such a quarterly journal?   yes/no

5. Would you be willing to submit papers to the journal?

6.  Do you think the title is appropriate?      yes/no

7.  Would you be interested in subscribing personally to the
journal?                                    yes/no

8.  Would you recommend your library to subscribe?

9. Which Journals are your first choice, when publishing papers within
Aims & Scope of this proposed Journal?

10. Approximately how many professionals at your institution
 or company would be likely readers of the journal?

11. Please indicate on a scale of 1 to 10 how strongly you advise Kluwer
to launch this journal,
(1 = don't advise, 10 = strongly advise)

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