cytotoxic agents

Alex Kerin akerin at
Thu Feb 17 10:20:11 EST 2000


I am conducting some research on articular cartilage tissue explants. I
need to kill the chondrocytes, or at least stop them producing matrix
macromolecules,  without affecting the mechanical properties of the
tissue. I would prefer not to use freeze-thaw cycles as I am unconvinced
that properties will not change (although if nothing else is suggested,
I will have to do before and after freeze-thaw controls). It has been
suggested that I use Sodium Azide, but I have found no information on
concentration/incubation time to acheive cell death. If anyone has any
suggestions that would be great.

Regards, Alex Kerin

Center for Biomedical Engineering
Rm 38-377, M.I.T.
77 Massachusetts Avenue
Cambridge, MA 02139

Tel: + (617) 253 6944
Fax: + (617) 258 5239
Email: akerin at

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