Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans

Rcjohnsen rcjohnsen at aol.com
Tue Jul 24 09:51:03 EST 2001


Cell Biology  

Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans 

Peter Baumann, Thomas R. Cech*  
Telomere proteins from ciliated protozoa bind to the single-stranded G-rich DNA
extensions at the ends of macronuclear chromosomes. We have now identified
homologous proteins in fission yeast and in humans. These Pot1 (rotection f
elomeres) proteins each bind the G-rich strand of their own telomeric repeat
sequence, consistent with a direct role in protecting chromosome ends. Deletion
of the fission yeast pot1+ gene has an immediate effect on chromosome
stability, causing rapid loss of telomeric DNA and chromosome circularization.
It now appears that the protein that caps the ends of chromosomes is widely
dispersed throughout the eukaryotic kingdom.  
Howard Hughes Medical Institute, Department of Chemistry and Biochemistry,
University of Colorado, Boulder, CO 80309, USA. 
*   To whom correspondence should be addressed. E-mail:
thomas.cech at colorado.edu 

CELL BIOLOGY:
Enhanced: Telomere Capping--One Strand Fits All.

Titia de Lange 
Science 2001 292: 1075-1076. (in Perspectives) [Summary] [Full Text]   



Volume 292, Number 5519, Issue of 11 May 2001, pp. 1171-1175. 
Copyright © 2001 by The American Association for the Advancement of Science.  



















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