[Cell-biology] P53, a key player in breast cancer: an update

scimedweb at mail.com scimedweb at mail.com
Tue Jan 24 09:36:58 EST 2006


"P53 and breast cancer, an update."

By Marc Lacroix, Robert-Alain Toillon, Guy Leclercq
Jean-Claude Heuson Breast Cancer Lab, Institut Jules Bordet Institute,
Bruxelles (Brussels), Belgique (Belgium)
 in press in Endocrine-Related Cancer

http://www.geocities.com/m.lacroix/erc2.htm


P53 plays a key role in mediating cell response to various stresses,
mainly by inducing or repressing a number of genes involved in cell
cycle arrest, senescence, apoptosis, DNA repair, angiogenesis.
According to this important function, P53 activity is controlled in a
very complex manner, including several auto-regulatory loops, through
the intervention of dozens of modulator proteins (the P53 interactome).
P53 mutations are observed in a significant minority of breast tumours.
 In the remaining cases, alterations of interactome components or
target genes could contribute, to some extent, to reduce the ability of
P53 to efficiently manage stress events. While the prognostic and
predictive value of P53 is still debated, there is an increasing
interest for P53-based therapies. The present paper aims to provide
updated information on P53 regulation, function, mutation and use in
therapy, with specific interest on its role in breast cancer.



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