[Cell-biology] Markers, detection and significance of disseminated breast cancer cells.

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Significance, detection and markers of disseminated breast cancer
cells.
by Marc Lacroix
InTextoResearch, Baelen, Wallonia, Belgium & Jules Bordet Institute,
Brussels, Belgium
in Endocrine-Related Cancer (in press)

http://www.geocities.com/m.lacroix/erc3.htm
http://journals.endocrinology.org/erc/fca/ERC00001.htm


The development of distant metastases is the major cause of death from
breast cancer. In order to predict and prevent tumour spreading, many
attempts are being made to detect small numbers of tumour cells that
have shed from the primary lesions and have moved to lymph nodes, blood
or bone marrow. A review presents the advantages and limitations of
techniques used for disseminated tumour cells (DTC) detection in breast
cancer. DTC markers are listed and the most currently used of them
(KRT19, CEACAM5/CEA, TACSTD1/GA733-2/M4S1, MUC1, EGFR, ERBB2,
SCGB2A2/MAMMAGLOBIN, SCGB2A1/MAMMAGLOBIN2, SCGB1D2, PIP/GCDFP15, SBEM,
TFF1/pS2, TFF3, ANKRD30A/NY-BR-1, SPDEF/PDEF, ESR1, SERPINB5/MASPIN,
and GABRP) are discussed, notably on the basis of recent data on breast
tumour portraits ("luminal epithelial-like",
"basal/myoepithelial-like" and "ERBB2/Her2/neu"). The
significance of DTC for prognosis and prediction of response to therapy
is examined. DTC viability, the notion of cell dormancy and the concept
of breast cancer stem cells are also discussed.



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