[Cell-biology] MicroRNAs: new essential actors in breast cancer ?

SciMedWeb via cellbiol%40net.bio.net (by scimedweb from mail.com)
Wed Dec 16 06:30:39 EST 2009


MicroRNAs in Breast Cancer
by Marc Lacroix
InTextoResearch, Baelen, Wallonia, Belgium.
in Breast Cancer: Causes, Diagnosis and Treatment, Nova Sciences
Publishers, ISBN 978-1-60876-463-1 (2010).

MicroRNAs (miRNAs) are a recently discovered class of small regulatory
RNAs that influence the stability and translational efficiency of
target mRNAs. Alterations in miRNA expression are associated with an
increasing number of biological processes, including breast cancer.
Some miRNAs are down-regulated in breast tumors, such as miR-21,
miR-155, miR-373, and miR-520c, and appears as putative tumor
suppressors. Other miRNAs are up-regulated, such as miR-126, and
miR-145, and members of the let-7 family; functional studies support
their oncogenic nature. miRNAs associated with estrogen receptor
expression and function, such as miR-181, miR-206, miR-221 and
miR-222, have also been identified. Of peculiar interest are miRNAs
(miR-200 family members, miR-205) involved in epithelial-mesenchymal
transition (EMT), a process that is likely to play an important role
in cancer cell metastasis. Functional assays and the developpement of
highly sensitive methods to detect miRNAs will undoubtedly lead to
rapid advances in a field that could considerably change our vision of
breast cancer biology.

MicroRNAs examined:

let-7a, let-7b, let-7c, let-7d, let-7e, let-7g, let-7i, let-7f, miR-7,
miR-9, miR-10, miR-15  & miR-16, miR-17 and the miR~17~92 cluster,
miR-20, miR-21, miR~23a~27a~24-2 & miR~23b~27b~24-1 clusters, miR-26,
miR-29, miR-30, miR-31, miR-34, mir-98, mir-103, mir-107, mir~106a~363
& mir~106b~25 clusters, miR-122, mir-124, mir-125, miR-126, mir-127,
miR-128, miR-130, miR-140, miR-141, miR-145, miR-146, miR-148,
miR-152, miR-155, miR-181, mir-196, miR-200 family, miR-205, miR-206,
miR-210, miR-213, miR~222~221 cluster,  miR-224, miR-320, miR-335,
miR-342 , miR-365, miR-373, miR-429, miR-489, miR-497, miR-499,
miR-516, miR-520, miR-663

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