[Chlamydomonas] postdoctoral position, Berlin

Elizabeth Harris via chlamy%40net.bio.net (by chlamy At duke.edu)
Tue Jan 2 11:57:06 EST 2007

[posted for Peter Hegemann]

Dear Chlamy researchers and friends

could you please announce the following position

many thanks and success for 2007

Peter Hegemann

PhD and/or Postdoc position in Berlin

Expression and Spectroscopic Characterization of Channelrhodopsins

The behavior of green algae like Chlamydomonas in their light 
environment is controlled predominantly by two sensory 
photoreceptors, Channelrhodopsin-1 (ChR1) and Channelrhodopsins-2 
(ChR2). Both were only recently found (1-4) and represent a new class 
of rhodopsins with intrinsic ion conductance or, in other words, a 
new class of ion channels with intrinsic light-activated gate. The 
differential function of ChR1 and ChR2 is not completely clear, but 
meanwhile it is known that both are involved in photophobic response 
and phototaxis.
During the last 2 years Channelrhodopsins received enormous attention 
by neurophysiologists who expressed ChR2 in various neuronal tissues, 
where ChR2 allows generation of action potentials simply by light 
For a detailed functional analysis we are inviting enthusiastic 
candidates to over-express channelrhodopsins in yeast, in cell 
culture systems (SF9, COS1) and in Chlamydomonas itself with the goal 
to purify enough protein for spectroscopic studies or finally 
structural analysis.

A solid background in molecular biology, and/or biophysics would be helpful.
We will provide the coolest city in Europe, a highly 
interdisciplinary and international research group, and enough 
support for any experiment that seems to be useful.
Candidates should send an application letter and CV to Peter 
Hegemann, (Hegemann At rz.hu-berlin.de) 

1) Ehlenbeck et al (2001) Evidence for a light-induced H+-conductance 
in the eye of the green alga Chlamydomonas reinhardtii. Biophys. J. 
82,740-751. 2) Nagel et al. (2002) Channelrhodopsin-1, a light-gated 
proton channel in green algae. Science 296, 2395 - 2398. 3) Nagel et 
al. (2003) Channelrhodopsin-2, a light-gated cation channel in green 
algae. Proc. Natl. Sci USA 100 (24), 13940 - 13945. 4) Hegemann et 
al. (2005) Multiple Photocycles of Channelrhodopsin. Biophys. J. 89, 
3911-3918. 5) Zhang et al. (2006) Channelrhodopsin-2 and optical 
control of excitable cells. Nat Methods. 3,785-92. 6) Parrish et al. 
(2006) Manipulating proteins for neuroscience. Curr Opin Neurobiol. 
16, 585-92.

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