There have been a number of questions here on the use of codon frequency
information to predict coding regions. Here are some references:
Bulmer, M. 1987. Nature 325:728-730.
Bulmer, M. 1988. J.Theor.Biol 133:67-71
Fickett, JW. 1982. Nuc.Acids.Res 10:5303-5318.
Recognition of protein coding regions in DNA sequences
Gribskov, M, J Devereux, and RR Burgess. 1984. Nuc.Acids.Res 12:539-549.
The codon preference plot: graphic analysis of protein coding
sequences and prediction of gene expression.
Li, W-H. 1987. J.Mol.Evol. 24:337-345.
McLachlan, AD. et al 1984 Nuc.Acids.Res 12:9567-9575.
Ohno, S 1988. PNAS 85:4378-4382.
Codon preference is but an illusion created by the construction
principle of coding sequences.
Sharp, PM and M. Bulmer. 1988. Gene 63:141-145.
Selective differences among translation termination codons.
Sharp, PM and W-H Li. 1986. J.Mol.Evol. 24:28-38.
Sharp, PM and W-H Li. 1987. Nuc.Acids.Res 15:1281-1295.
Sharp, PM et al. 1986. Nuc.Acids.Res 14:5125-5139.
Staden, R. 1984. Nuc.Acids.Res 12:505-519
Computer methods to locate signals in nucleic acid sequences
Staden, R. 1984. Nuc.Acids.Res 12:521-538
Graphic methods to determine the function of nucleic acid sequences
Staden, R. 1984. Nuc.Acids.Res 12:551-567
Measurements of the effects that coding for a protein has on a DNA
sequence and their use for finding genes.
Keith Robison
Harvard University
Program in Biochemistry, Molecular, Cellular, and Developmental Biology
robison at ribo.harvard.edu