PROTEIN STRUCTURE PREDICTION

Richard H. Lathrop rickl at ai.mit.edu
Tue Mar 17 11:40:00 EST 1992


				   
		     PROTEIN STRUCTURE PREDICTION:
       Subproblems and Alternative Approaches to Protein Folding
				    
		      Call for Papers and Referees
		For a Biotechnology Computing Minitrack
	Hawaii International Conference on System Sciences - 26
		  Kauai, Hawaii  -  January 5-8, 1993

The Biotechnology Computing Track of HICSS-26 will contain a special
session focusing on computational approaches to protein structure
prediction.  Our motivation is that individual computational researchers
have recently made progress on a number of subproblems and alternative
approaches to the protein folding puzzle, and that we are now (or soon
will be) in a position to begin to stitch these pieces together.  This
minitrack will bring together researchers who have taken widely varying
approaches to the problem, in order to explore the possibility of
constructive interaction and integration of the methods in a
workshop-like atmosphere.

The intent of this mini-track is two-fold:

 * First is to facilitate communication: to directly exchange
   information and ideas between workers in the area, and to provide a
   forum for the presentation of the latest results in all approaches
   to the protein folding problem.

 * Second, is to encourage discussions of synergies: to explore how
   the different approaches to different sub-problems fit together,
   to examine what mutual light they may shed on each other, and to
   grope toward a unifying framework within which the constraints
   imposed by solutions to sub-problems may interact to impose yet
   more powerful constraints on the overall protein folding problem.

ALL COMPUTATIONAL ASPECTS OF THE PROTEIN FOLDING PROBLEM ARE OF INTEREST.
THESE INCLUDE (BUT ARE NOT LIMITED TO):

        * core domain and tertiary topology prediction
        * amino acid packing and residue-residue contact studies
        * secondary structure or main chain torsion angle analysis
        * lattice folding models
        * synthetic or simulated energetics or potentials
        * predicting side-chain conformation
        * multiple-alignment or homology-derived techniques
        * distinguishing native from incorrectly folded models
        * amino acid environment matching
        * mutational analysis and the contribution of single amino acids
        * statistical, machine learning and multi-strategy systems

We encourage papers that describe working implemented systems
integrating multiple methods and approaches, or that present data and
analysis exploring the relationships among alternative characterizations
of the protein folding problem.


INSTRUCTIONS FOR AUTHORS:

Manuscripts should be 22-26 typewritten, double-spaced pages in 10 or
12 point type; do not send submissions significantly longer or
shorter.  Papers must not have been previously presented or published,
nor currently submitted for journal publication.  Each manuscript will
be refereed by at least five reviewers.  Manuscripts should include a
title page that identifies the title of the paper, the full name(s) of
the author(s), affiliation(s), complete mailing and electronic
address(es), telephone number(s) and a 300 word abstract of the paper.

Members of the community willing to serve as referees should send
their name, electronic and physical address, phone number, and areas
of interest to the program chair.  Authors of submissions to this
minitrack may not serve as referees.

DEADLINES:

* A 300 word abstract:  May 1, 1992
* Feedback to the author concerning the abstract:  May 11, 1992
* Papers due to minitrack chairs:  5 June 1992
* Notification of paper acceptances:  31 August 1992
* Camera Ready copy due to minitrack chairs:  1 October 1992.

* The conference itself is Jan 5-8, 1993 in Kauai, Hawaii


SEND SUBMISSIONS AND QUESTIONS TO:

        Richard H. Lathrop
        MIT AI Lab, NE43-795
        545 Technology Sq.
        Cambridge, MA 02139
        USA

        rickl at ai.mit.edu
        (617) 253-8833
        (617) 258-8682 (fax)



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