anyone looked at long-range patterns in DNA sequence?

Xuhua Xia xia at hardy.u.washington.edu
Tue Mar 23 18:15:22 EST 1993


In article <1993Mar17.153421.21757 at husc3.harvard.edu> mlevin at husc8.harvard.edu (Michael Levin) writes:
>
>     Has anyone looked at long-range (much larger scale than average
>gene sizes) pattern in the genomes of various organisms? What I mean
>is, to take the entire (known) sequence of the genome of some
>organism, and treat it as a single long message in a 4-letter
>alphabet, ignoring the gene/promoter/etc. boundaries, to look for
>long-scale patterns. Has this been done or discussed anywhere? I would
>appreciate references. If such patterns were discovered, what would
>this imply? What tools (mathematical) can be used to look for patterns
>in a string of symbols (when the pattern isn't known in advance)?
>Please send ideas to mlevin at husc8.harvard.eddu.
>
>Mike Levin
>

You can use time series with different time (base) lags. What pattern
are you suspecting? It sounds pretty wild.

Xuhua Xia



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