COMPUTATIONAL ANALYSIS OF EUKARYOTIC TRANSCRIPTIONAL REGULATORY ELEMENTS

[Holger Karas]

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                 International Workshop on

                COMPUTATIONAL ANALYSIS OF
       EUKARYOTIC TRANSCRIPTIONAL REGULATORY ELEMENTS

                  on January 18-20, 1996
   at the German Cancer Research Centre, Heidelberg, Germany

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Algorithmic recognition of gene promoters has been of interest for
many years, in part for the possibility of shedding light on the
mechanisms of transcription, and in part because it is an important
component of the gene identification problem. In the last few years
this old problem has changed in character, growing in difficulty, in
interest, and in opportunities for application.  
Fundamentally, this change comes from 
(1) the realization that, at least in eukaryotes,
    there are no simple patterns characteristic of all promoters
(2) a huge increase in knowledge of the transcriptional regulatory
    mechanisms of specific genes and classes of genes, and
(3) the new opportunities and needs created by the large scale cDNA and 
    genome sequencing projects.  
With this change has come a increased willingness to apply
computational approaches to problems in the field of transriptional
regulation, ranging from the characterizion of individual gene
regulatory elements to the analysis of complex transcriptional control
regions acting through synergistic effects of mutliple DNA-binding
proteins. The possibility of predicting the transcriptional context of
a gene may also yield hints as to its function. Important applications
are in the search for so-called 'disease genes' and in the design of
pharmaceuticals.

The emphasis of this workshop will be the computational recognition of
eukaryotic transcriptional regulatory regions of genes and, the
determination of the conditions under which they are active. This
meeting will allow to scientists from both the theoretical and
experimental fields to work together and exchange information.

Organizing Committee:

Phillip Bucher ( ISREC , Lausanne , Switzerland )
Jim Fickett ( Los Alamos , USA )
Artemis Hatzigeorgiou ( coordinator ) ( DKFZ , Heidelberg , Germany )
Edgar Wingender ( GBF , Braunschweig , Germany )

Speakers will include:

Benham G., Dep. of Biomathem. Sciences, New York, USA
Chen Q., Univ. of Colorado , Boulder, USA 
Claverie J.M., C.N.R.S., France
Kalogeropoulos A., Cent. Univ. d'Orsay, France 
Kolchanov N.A., Novosibirsk, Russia
Langowski J., DKFZ, Heidelberg, Germany 
Mermod N., Univ. of Lausanne, Switzerland
Pontoglio M., Inst. Pasteur, Paris, France 
Prestridge D.S., Univ. of Minnesota,  USA 
Sklenar H., Max-Delbrueck-Centrum, Berlin , Germany
Trifonov E., Weizmann Inst. of Science, Israel 
Tronche F., C.N.R.S., France 
Werner T., GSF Neuherberg, Germany 

Contributions from computer science, experimental biology, genome
research, mathematics and biophysics are invited for oral and poster
presentations. Submissions for the workshop can be sent in the form
of an extended abstract or a full paper. Accepted contributions will 
be collected as a booklet and distributed to the participants.

Deadline for poster submissions is December 16, 1995
Deadline for registration is January 11, 1996

The Workshop is sponsored by the European Union, 
the German Cancer Research Centre and Silicon Grafics.

Further information:

Artemis Hatzigeorgiou
Molecular Biophysics (0810), German Cancer Research Centre 
Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Tel. (+49) 6221 - 422339, Fax (+49) 6221 - 422333
email: Artemis at dkfz-heidelberg.de
and http://genome.dkfz-heidelberg.de/nnga/ws-trans.html


Registration form :

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Workshop on :   COMPUTATIONAL ANALYSIS OF
       EUKARYOTIC TRANSCRIPTIONAL REGULATORY ELEMENTS

on January  18-20, 1996, at the German Cancer Research Centre, Heidelberg,
Germany

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