How to predict transmembrane protein topology?
ray at helix.nih.gov
Mon Oct 2 15:31:30 EST 1995
In article <4486ld$dpu at news.ust.hk>, bclong at uxmail.ust.hk (Terence) wrote:
> I often read in journals that a certain transmembrane topology is
>determined/predicted for a certain transmemnrane protein. How is this done?
>Is this done thru some commercial/public domain software? Or is it just by
>eyeballing how many hydrophobic segment there?
A relatively naive approach is described in a paper, "Neural Net Models to
Characterize Integral Membrane Proteins - Preliminary Report" to appear in
Zeitschrift fuer Angewandte Mathematik und Mechanik (ZAAM) as part of the
Proceedings of ICIAM95. A complete preprint is available via anonymous
ftp in file smb/pubs/Mejia_ICIAM95.tar.Z on fconvx.ncifcrf.gov
(184.108.40.206). I welcome your comments and suggestions.
You may browse the the contents of the ftp archive via the Society for
Mathematical Biology Home Page at URL:
Laboratory of Kidney and Electrolyte Metabolism, NHLBI, and
Mathematical Research Branch, NIDDK
National Institutes of Health
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Tel: (301)496-9972 Fax: (301)402-0535
E-mail: ray at helix.nih.gov WWW: http://mrb.niddk.nih.gov/ray/
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