ANNOUNCEMENT: Signal peptide prediction (new version)

Henrik Nielsen rna!hnielsen at
Thu Dec 12 00:45:13 EST 1996

The SignalP World Wide Web server,
predicts signal peptides of secretory proteins.  For cleaved signal
peptides, the precise location of the cleavage site in the amino acid
sequence is predicted.  The prediciton is optimised for three different
types of organisms: Gram-positive prokaryotes, Gram-negative
prokaryotes, and eukaryotes.  The method incorporates a prediction of
cleavage sites and a signal peptide/non-signal peptide prediction based
on a combination of several artificial neural networks.

The server has recently been updated to version 1.1.  The calculation of
the cleavage site scores is slightly improved relative to the earlier

Form the server, you can access several pages of information about the
data and results, including amino acid and length distributions of
signal peptides.  This documentation has been extended substantially in
the new version.

SignalP V1.1 is also available as a mail server.  For instructions,
send a mail to
        signalp at
containing the word "help" only.

The article about SignalP:
"Identification of prokaryotic and eukaryotic signal peptides and
prediction of their cleavage sites" by
Henrik Nielsen, Jacob Engelbrecht, Soeren Brunak and Gunnar von Heijne
is due to appear in Protein Engineering, vol. 10, issue 1, 1997.
Preprints can be requested by mail to Henrik Nielsen,
hnielsen at

Henrik Nielsen

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