Detection of mutations in protein superfamilies

[Sergey Shmul Levin]

Can anybody give me some pointers towards algorythms for detection of mutations
in protein superfamiles? DOTPLOT can be used to see dissimilarites in the
alignment pairs (what is the original refernce for it, though?), but what if I
am looking at an alignment of a number of proteins, is there any methods to
catch and evaluate non-conservative mutations?
Thanks in advance for any information or advice.

======================== Sergey "The Shmul" Levin  ==========================
Albert Einstein College Of Medicine           || lab  (718) 430 4064 
Department of Anatomy and Structural Biology  || beep (917) 268 1754        
e-mail slevin at telico.bioc.aecom.yu.edu        || Ullman 905