On 18 Jan 1997, Jeffrey Taylor wrote:
> I've got a poster on my wall that illustrates many of the major
> metabolic pathways such as the citric acid cycle, pentose pathway, urea
> cycle, etc. It seems that there is a simulation waiting for me to code
> it in there somewhere and I'd like to hear from anyone who is working on
> such a project.
>> Jeff Taylor
>>> --
> =-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-
> Jeffrey S. Taylor Molecular Modeling
> The Wistar Institute and Software development
> The University of Pennsylvania Molecular Biology
> Philadelphia, PA 19104 E-Mail Jeff at aries.wistar.upenn.edu> (215) 898-2202 WWW http://adeno.wistar.upenn.edu>>>
well, the first thing to do is to find all the enzymatic equations
of the pathways you want to modelise. And this won't be as easy
as it seems !!
second, you will discover what the word stiff means. because to modelise
a pathway is equivalent to solve a set of differential equation.
The time constant of these ODE are varying in a big order of magnitude.
By the way you should read the papers of, for exemple, Heinrich ;
Rappoport ; Fell and lot of other
Good luck ;-)
