In article <2a7cd$15113b.3c4 at enzyme.demon.co.uk>, Pedro Mendes
<pedro at enzyme.demon.co.uk> writes
>In article <32FB5557.15B5 at ibsm.cnrs-mrs.fr>, athel at ir2cbm.cnrs-mrs.fr says...
>>Herbert Sauro replied:
>>>>"Your're only about about 50 to 60 years too late. Metabolic modelling
>>has been going on for quite some time..."
>>>>Maybe true, if a little unkind, but don't worry, there is plenty left to
>>do. Actually, I don't know who was doing much of this sort of thing 50
>>years ago, let alone 60 (what did they do it on? an abacus?). It mainly
>>started with Garfinkel & Hess in the 1960s.
>>>>more than 50 years ago (1943) Britton Chance published simulations done
>with a mechanical differential analyzer (they were actually on one isolated
>enzyme not a pathway), but Athel is right,this was one isolated study and
>it all began around 1960 with Chance Garfinkel and Hess. I would be very
>interested in finding out about *any* computer simulation in biochemistry 60
>years ago :)
>I did say 50 to 60 years ago, so 54 years ago is not a bad guess!
Herbert
--
Herbert M Sauro
Future Skill Software (Specialists in Science Software for Education)
email: HSauro at fssc.demon.co.uk
Telephone: 01974 282428
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