Computational Genomics Course

William R. Pearson wrp at
Tue Jul 15 17:21:45 EST 1997

Computational Genomics

November 6 - November 11, 1997

William Pearson, University of Virginia
Randall Smith, Smith-Kline Beecham

Application Deadline July 15, 1996

(Although today is the deadline, I suspect that applications will
be accepted until the end of the week - WRP)

This course presents a comprehensive overview of the theory and
practice of computational methods for gene identification and
characterization from DNA sequence data. The course focuses on
approaches to extracting the maximum amount of information from
protein and DNA sequence similarity through sequence database
searches, statistical analysis, multiple sequence alignment, and
phylogenetic analysis. Additional topics include gene recognition
(exon/intron prediction), identifying signals in unaligned sequences,
and integration of genetic and sequence information in biological
databases. The course combines lectures with hands-on exercises;
students are encouraged to pose challenging sequence analysis problems
using their own data. The course is taught using Unix workstations,
and participants are expected to be comfortable using the Unix
operating system, programs, and a Unix text editor (programming
knowledge is not required). The course is ideal for biologists seeking
advanced training in biological sequence analysis, computer core
directors and staff for molecular biology or genetics resources, and
for scientists in other disciplines, such as computer scientists, who
wish to survey current research problems in biological sequence

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