In article <87vgv6$ccl$1 at mercury.hgmp.mrc.ac.uk>,
William.Nelson at karobio.se (William Nelson) wrote:
> Transcription factors, for the most part, determine the
> expression levels of genes in different tissues. I want to begin looking
> at
> some of the correlations between transcription factors and genes with
> respect to different types of human tissue (heart vs. brain vs. kidney
> etc.).
> My idea is to look at ESTs generated from different tissues and identify
> those ESTs that correspond to known genes. Then I want to search
> PubMed or some other database and determine whether or not a particular
> gene is associated with a particular transcription factor. I would like
> to make this strategy as automatic as possible because I don't want to
> burn out my eyes staring at the computer screen 24 hours a day.
> Any suggestions are more than welcome.
>> //William Nelson
> Stockholm, Sweden
Associated ESTs with tissues is essentially what has been done at the NCBI
Cancer
Genome Anatomy Project
http://www.ncbi.nlm.nih.gov/CGAP/hTGI/
Perhaps that can be a starting point for you.
--
Stuart M. Brown
Bioinformatics Consultant
NYU Medical Center, 550 First Ave, NY, NY
