In article <pgpmoose.200207100312.27147 at net.bio.net>, Ulrik wrote:
> I'm looking for the theoretical structure of human thymmidine kinase 1
> (hTK1). I know it's been created by Gerd Folkers in 1991, but he never
> uploaded it to The Protein Data Bank nor does he answer e-mails.
Good thing it wasn't uploaded to PDB. Until quite recently PDB was
contaminated with several theoretical structures, and one had to be
very careful to filter these out whenever using PDB. They have now
been moved into a separate repository, so that PDB now reports only
models for which there is strong experimental evidence.
> Does any have any idea where I can find the theoretical structure of the
> enzyme?
Unless the theoretical model had some good experimental data behind
it, you are better off creating a new theoretical model---modelling
techniques for remote homologs have improved a lot since 1991, and
there is a lot more data in the PDB and protein sequence databases to
work with. You could start with one of the metaservers, such as the
one at bioinfo.pl/meta
--
Kevin Karplus karplus at soe.ucsc.eduhttp://www.soe.ucsc.edu/~karplus
Professor of Computer Engineering, University of California, Santa Cruz
Undergraduate Director, Bioinformatics
Affiliations for identification only.
