Hi All,
I'm trying to fit a set of scores I get from searching a database of
1000 amino acid sequences with a HMM. I want to calculate a p-value
for each matching score. My questions are
a) How do you estimate the scalling factors K and Lambda to fit my
scores (1000) to an extreme value distribution?
b) How do I then calculate a p-value/E-value from this ditribution for
a given score?
thanks in advance,
Ranjeeva