estimating K and Lambda from an extreme value distribution

Ranjeeva ranjeeva_r at
Fri Feb 20 01:05:33 EST 2004

Hi All,

I'm trying to fit a set of scores I get from searching  a database of
1000 amino acid sequences with a HMM. I want to calculate a p-value
for each matching score. My questions are

a) How do you estimate the scalling factors K and Lambda to fit my
scores (1000) to an extreme value distribution?

b) How do I then calculate a p-value/E-value from this ditribution for
a given score?

thanks in advance,


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