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[Computational-biology] Job: Research Fellow in Genomics/Bioinformatics

John Kenneth Colbourne jcolbour at cgb.indiana.edu
Sun Oct 2 11:07:51 EST 2005

The Center for Genomics and Bioinformatics (CGB Indiana University, 
Bloomington) carries out research in genomics, bioinformatics and is a 
principle laboratory of the Daphnia Genomics Project. This project creates 
genomic resources for a developing model organism in ecological and 
evolutionary genomics research. These resources include a 9-fold sequence 
coverage of the genome that was produced by the U.S. Department of Energys 
Joint Genome Institute in collaboration with the Daphnia Genomics 
Consortium. As a result, Daphnia will soon have the best characterized 
genome among Crustacea and will ultimately be used to address issues 
relating to the genome structure of the arthropods.

The CGB has an immediate opening for a Research Fellow to help create and 
implement algorithms that will rigorously test and help improve the 
assembly of the genome sequence. The research fellow will also participate 
in the exploration and interpretation of the data. This position is 
initially funded for one year and is ideal for investigators who have 
recently completed their graduate studies in the field of computer science 
/ bioinformatics, or who are in the final stages of completing their 
dissertations. However, all candidates with expertise in computer 
programming and prior experience with genome sequencing projects are 
encouraged to apply, including visiting scientists. We offer a competitive 
salary ($57,000 plus benefits) and access to state of the art facilities.

Specifically, this project aims to improve the assembly of the Daphnia 
genome by developing two computational methods for detecting misassembled 
regions, one based on pattern statistics and another based on clone 
coverage statistics. These independent algorithms are already proven to 
accurately detect false assemblies in microbial genome sequencing 
projects. These two algorithms will be refined and combined to provide a 
probabilistic support index for scaffold junctions and will function on 
much larger and more complex eukaryotic genomes, including Daphnia. A 
significant outcome is the creation and implementation of a support index 
along localized regions of genome sequence assemblies to indicate regions 
of high and low confidence.

Applications will be accepted until October 31, 2005. Interested 
candidates may contact John Colbourne for further information (by sending 
email to jobs at cgb.indiana.edu). Please submit a CV and a description of 
your background and interests, and have three (3) letters of 
recommendation sent directly to the address below. Be sure to refer to 
Research Fellow CGB-008 within your cover letter.

Position #CGB-008
Attn: Research Fellow
Center for Genomics and Bioinformatics
Indiana University
1001 E. 3rd St.
Bloomington IN 47405-3700

Indiana University is an affirmative action equal opportunity employer.

Center for Genomics and Bioinformatics, Indiana University
915 East Third Street, Bloomington, Indiana USA 47405-7107
Daphnia Genomics Consortium - http://daphnia.cgb.indiana.edu/

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