[Computational-biology] Re: Point Specific Mutation Matrix vs. profile HMM ?

[Michael Spitzer]

Hi,

> Kevin Karplus, Rachel Karchin, George Shackleford, and Richard
> Hughey. Calibrating E-values for hidden Markov models with
> reverse-sequence null models. 

Thanks for the reference! I didn't watch HMM literature very closely
for the last year or so. Too late though for inclusion in my thesis
(just printed), but a good item for the defense, if the topic arises.
:-)

Cheers, Michael