[Computational-biology] Post-doctoral position: bioinformatics, LIRMM, Montpellier, France

brehelin from lirmm.fr via comp-bio%40net.bio.net (by brehelin from lirmm.fr)
Wed Apr 18 11:06:56 EST 2007



Post-doctoral position, LIRMM, Montpellier, France

A Post-doctoral position is available for up to 3 years in the "Method
and Algorithm for Bioinformatic" group (MAB) to join the PlasmoExplore
project. This project implies teams from CEA Grenoble (Eric Marechal),
the Museum d'Histoire Naturelle Paris (Isabelle Florent) and the
LIRMM, and is funded by the french National Research Agency.

MAB web page: http://www.lirmm.fr/mab/
PlasmoExplore web page: http://www.lirmm.fr/~brehelin/PlasmoExplore

Contact: Olivier Gascuel (gascuel from lirmm.fr) or Laurent Bréhélin
(brehelin from lirmm.fr).

The PlasmoExplore project aims at predicting the function of orphan
genes of P.falciparum, by exploiting the rapidly growing mass of
genomic and post-genomic data of the organism. This characterisation
should allow identifying new therapeutic targets for new
treatments. The proposed approach will combine : (1) the ontologies of
the Gene Ontology (GO) consortium, which define the function of genes;
(2) efficient methods of alignment able to account for the
compositional bias of the malarial genome, so as to exploit genomic
data and establish new homologies, at the gene scale but also at
chromosomes or entire genomes scales ; (3) supervised statistical
learning methods, that will be used to exploit post-genomic data and
build predictors associated with each GO class ; (4) classifier
combination methods to synthesize the information extracted from each
data source ; and finally (5) visualisation and interaction adapted
methods, allowing a multi-scale exploration of the predictions by end
users. The project will elaborate a free-access database on the web,
which will provide to the international scientific community the best
available predictions.

The candidate will work along these lines on functional prediction and
gene annotation of Plasmodium falciparum. He/She should have PhD in
bioinformatics, with special interest in statistical machine learning,
algorithmics, genomics, and(or) gene annotation. Please submit a
summary of research interests, CV, reprints of the main publications,
and reference contacts.




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