[Computational-biology] 2 years post-doc in cancer systems biology

[Ovidiu Radulescu]

A two years post-doctoral position is open at the Institute of
Mathematical Research in Rennes (France) for Computational Systems
Biology of Cancer, starting with September 1, 2007.

This position is created to support the participation of IRMAR to
the interdisciplinary project SITCON (Modeling signal transduction
induced by a chimeric oncogene) in collaboration with the Curie
Institute in Paris and with IRISA in Rennes (Symbiose team).

Job description:

Qualitative modeling of molecular pathways involved in the Ewing
inducible cellular model.

The role of this post-doc is to apply and to extend existant
qualitative approaches to heterogeneous data in cancer. These
approaches use qualitative equations, graph theoretical methods and
polynomial coding in Galois fields. Qualitative modeling will be
used for three purposes:

1) Construction and correction of graphical models which integrate
information from heterogeneous data: micro-arrays, micro-RNA,
ChIP-on-chip, CGH, time series. Data is provided by our
collaborators in Curie Institute.

2) Qualitative analysis of transduction pathways and of their
cross-talk.

3) Experiment design.

The successful candidate will collaborate with Ovidiu Radulescu in
IRMAR and with several members of the group Symbiose (computer
science, IRISA).


Requirements for candidates:

We expect the candidate to have formation in mathematics, physics or
computer science. Experience in modeling molecular mechanisms in
biology will be appreciated. It will be advantageous to be able to
demonstrate some knowledge of basic biological mechanisms involved
in cancer (regulation of cell cycle, apoptosis, etc.) and to have
experience of collaboration with biologists for solving concrete
biological problems. Another advantage will be familiarity with
standards in Systems Biology (SBML, BioPax) and with existing
software for pathway modeling. Programming skills are needed. Good
communication skills are required.


Job location:

Institute for Mathematical Research and IRISA, Campus de Bealieu,
35042 Rennes. This job offers true interdisciplinar environement.
IRMAR is one of the best university institutes in France, as well as
a world-class mathematical center. IRISA, a flexible and excellently
managed structure, strongly supports interdisciplinarity: many IRISA
teams host mathematicians, biologists and physicists working on
interdisciplinar projects. Rennes is a small, enjoyable university
town, in the pleasant to live Brittany (north-west of France), not
far from unique sea shore.


Contact for more information:

ovidiu.radulescu from univ-rennes1.fr


Links:

For more information about IRMAR:

For more information about IRISA:

Application:

Applicants should submit a letter of motivation (with reference ANR
SITCON), a detailed CV with publication list, and the names of
three referees by e-mail to  ovidiu.radulescu from univ-rennes1.fr