Need the plasmid containing the sequence for CR1

daemon at hgmp.mrc.ac.uk daemon at hgmp.mrc.ac.uk
Fri Apr 28 10:59:38 EST 2000


Good days, everybody ,
I have a question :  
Why there is not transgenic pigs expressing human CR1 to Overcome
complement-mediated 
hyperacute xenograft rejection ?
CR1 has extrinsic activity , i.e., it inactivates convertases assembled
on external 
membranes, and it also exhibits intrinsic activity ,i.e., it inactivates
convertases 
formed on the same membrane on  which it is expressed. Among the members
of the RCA 
family , CR1 is  the only one that possesses dcay-accelerating activity
for both C3 and 
C5 convertases in both the classical and alternative pathways,as well as
factor I  
cofactor activity for the  degradation of both C3b and C4b .

Would you please send me the plasmid containing the sequence for CR1 ?

Department of immunology
The Third Military Medical University
Gao tanyan,Sha pingba
Chongqing , 400038
People's Republic of China.
 
            Guo Bo
 E-mail:  immuno06 at mail.tmmu.com.cn

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